Occurrence of human papillomavirus types 16 and 18 in benign prostatic hyperplasia tissues of Saudi patients.

Human papillomavirus, type 16 (HPV-16) and type 18 (HPV-1 8) are known to play a role in the development of neoplastic disorders of the urogenital organs. The presence of HPV-1 6 and HPV18 in prostatic tissue with benign hyperplasia has been a matter of controversy. Some investigators have reported a high prevalence of HPV-16 DNA and a low prevalence of HPV-18 DNA in prostatic tissue,'-3 while others have failed to demonstrate either.4 6 In this study, we examined prostatic tissues of 19 cases of benign prostatic hyperplasia (BPH) from Saudi patients seen at our tertiary care medical centre to investigate the occurrence of both HPV-16 and HPV-18 DNAs by using the polymerase chain reaction Department of (PCR), followed by Southern blot hybridisaBiological and Medical tion (SBH) with type-specific probes. We also Research (MBC-03) obtained void urine samples from the same